Hersteller |
Boster
|
Kategorie |
|
Typ |
Proteins Recombinant |
Specific against |
other |
Format |
Solution |
Menge |
10ug |
ArtNr |
BOS-PROTP58753 |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Lieferbar |
|
Contents |
The TIRAP solution (0.25mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 200mM NaCl, 2mM DTT and 20% glycerol. |
Description |
TIRAP Human Recombinant produced in E. coli is a single polypeptide chain containing 244 amino acids (1-221) and having a molecular mass of 26.3 kDa. TIRAP is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
Gene name |
TIRAP |
Protein function |
Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6. |
Purification |
Greater than 90% as determined by SDS-PAGE. |
Shipping |
Shipped with wet ice |
Short description |
TIRAP Human Recombinant produced in E. Coli is a single polypeptide chain containing 244 amino acids (1-221) and having a molecular mass of 26.3 kDa. TIRAP is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
Storage |
Store in -20° C for long term storage. After reconstitution, store in 4° C for short term usage within a few days. Avoid freeze-thaw cycles. |
Subcellular localization |
Cytoplasm |
Tissue specificity |
Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain. |
Format Information |
Sterile Filtered colorless solution. |
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