Vergleich

GRINA Antibody

ArtNr ABC-ASC11587
Hersteller Abcepta
Menge 100 ug
Kategorie
Typ Antibody Primary
Applikationen WB, ELISA
Specific against other
Host Rabbit
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Lieferbar
Primary Accession
Q7Z429
Application
WB, E
Bio Background
GRINA Antibody: The transmembrane BAX inhibitor motif (TMBIM) family of proteins includes the founder member TMBIM6/BI-1, TMBIM1/RECS1 (responsive to centrifugal force and shear stress gene 1 protein), TMBIM2/LFG (life guard), TMBIM3/GRINA (glutamate receptor ionotropic NMDA protein 1), TMBIM4/GAAP (Golgi anti-apoptotic-associated protein), and TMBIM5/GHTIM (growth hormone-inducible transmembrane protein). They are highly conserved in mammals and zebrafish and contain a conserved BAX inhibitor-1 motif. GRINA is expressed in the brain and is a potential apoptotic regulator.
Bio References
Yamaji T, Nishikawa K and Hanada K et al. Transmembrane BAX inhibitor motif containing (TMBIM) family proteins perturbs a trans-Golgi network enzyme, Gb3 synthase, and reduces Gb3 biosynthesis. J. Biol. Chem. 2010; 285:35505-18.
Nielsen JA, Chambers MA, Romm E, et al. Mouse transmembrane BAX inhibitor motif 3 (Tmbim3) encodes a 38 kDa transmembrane protein expressed in the central nervous system. Mol. Cell. Biochem. 2011; 357:73-81.
Rojas-Rivera D, Armisén R, Colombo A, et al. TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis. Cell Death Differ. 2012; 19:1013-26.
Clonality
Polyclonal
Gene ID
2907
Gene Name
GRINA
Reactivity
H
Legend image 1
Western blot analysis of GRINA in human testis tissue lysate with GRINA antibody at (A) 1 and (B) 2 µg/mL.
Type image 1
WB
Other Accession
NP_001009184; 57165375
Isotype
IgG
Calculated MW
41203
Antigen Source
homo sapiens
Target/Specificity
GRINA; GRINA antibody is predicted to not cross-react with other members of the TMBIM family.
Purification
GRINA Antibody is affinity chromatography purified via peptide column.
Reconstitution & Storage
GRINA antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
Antibody Form
Liquid
Application Notes
GRINA antibody can be used for detection of GRINA by Western blot at 1 - 2 µg/mL.
Positive Control
Human Testis Tissue Lysate;
Buffer
GRINA Antibody is supplied in PBS containing 0.02% sodium azide.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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