AIMP2 Antibody

ArtNr	ABC-ASC11715
Hersteller	Abcepta
Menge	100 ug
Kategorie	Neuroscience Aging & Neurological Disorders Antibodies Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies Immunostaining
Typ	Antibody Primary
Applikationen	WB, IF, ELISA, IHC-P
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Citations	Quevillon S, Robinson JC, Berthonneau E, et al. Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein. J. Mol. Biol. 1999; 285:183-95. Ko HS, von Coelln R, Sriram SR, et al. Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death. J. Neruosci. 2005; 25:7968-78. Choi JW, Kim DG, Park MC, et al. AIMP2 promotes TNFalpha-dependent apoptosis via ubiquitin-mediated degradation of TRAF2. J. Cell Sci. 2009; 122:2710-5. Choi JW, UM JY, Kundu JK, et al. Multidirectional tumor-suppressive activity of AIMP2/p38 and the enhanced susceptibility of AIMP2 heterozygous mice to carcinogenesis. Carcinogenesis 2009; 30:1638-44.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Lieferbar
Manufacturer - Category	Primary Antibodies; Cell Biology; Neuroscience
Manufacturer - Targets	AIMP2; AIMP2 antibody is human specific. AIMP2 antibody is predicted to not cross-react with AIMP1.
Storage Conditions	AIMP2 antibody can be stored at 4? for three months and -20?, stable for up to one year.
Bio Background	AIMP2 was initially identified as a part of an aminoacyl-tRNA synthesase complex (1). It was later discovered to be a cofactor and substrate of Parkin, a Ring-type E3 ubiquitin ligase that is important for the survival of dopamine neurons in Parkinson’s disease; accumulation of AIMP2 in these cells lead to catecholaminergic cell death (2). AIMP2 can also bind to TRAF2, a key player in the TNF-alpha signaling pathway, causing the ubiquitination of TRAF2 by cIAP1, leading to TNF-alpha-dependent apoptosis (3). Finally, AIMP2 has been suggested to function as a tumor suppressor (4).
Clonality	Polyclonal
Gene Name	AIMP2
Reactivity	H
Calculated Molecular Weight	35349
Antigen Source	homo sapiens
Purification	AIMP2 antibody is affinity chromatography purified via peptide column.
Antibody Form	Liquid
Application Notes	AIMP2 antibody can be used for detection of AIMP2 by Western blot at 1 - 2 µg/ml.
Positive Control	HeLa Cell Lysate
Buffer	AIMP2 antibody is supplied in PBS containing 0.02% sodium azide.

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Menge: 100 ug

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Lieferung vsl. bis 04.12.2025

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