Human CCR7 Full Length Protein, His,Flag Tag (Detergent)

Protein

Dry ice

58.9 kDa

The monoclonal antibody mAb-729 reacts with the human CC chemokine receptor, CCR7. The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis.

CCR7

This protein carries a polyhistidine tag at the C-terminus, followed by a Flag tag. The protein has a calculated MW of 58.9 kDa.

50 mM HEPES, 150 mM NaCl, Buffer B, pH7.5

glycerol