Mouse Anti-Human CASP3 Clone C33 mAb

Mouse Anti-Human Caspase 3 Clone C33 monoclonal antibody. The caspase family of cysteine proteases play a key role in apoptosis. Caspase 3 is the most extensively studied apoptotic protein among caspase family members. Caspase 3 is synthesized as inactive pro-enzyme that is processed in cells undergoing apoptosis by self-proteolysis and/or cleavage by another upstream protease. The processed form of caspase 3 consists of large (17 kD) and small (12 kD) subunits which associate to form an active enzyme. The active caspase 3 proteolytically cleaves and activates other caspases, as well as relevant targets in the cells (e.g. PARP and DFF).

Recombinant human caspase 3

Recognizes both proform and the cleaved fragments of caspase 3.