Mouse Anti-Human VEGFR-2/KDR Clone 4 (20I6) mAb

Hersteller Cell Sciences
Kategorie
Typ Antibody
Specific against Human
Clon 4(20I6)
Isotype IgG1
Applikationen WB, FC, IF, IHC, ELISA
Menge 100 ug
Host Mouse
ArtNr CS-CMV016
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Applications
ELISA, WB, IHC, IF, FC
Description
VEGF R1 (Flt-1), VEGF R2 (KDR/Flk-1), and VEGF R3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domain and kinase insert domains in their intracellular region. They are best known for regulating VEGF family-mediated vasculogenesis, angiogenesis, and lymphangiogenesis. They are also mediators of neurotrophic activity and regulators of hematopoietic development. Human VEGF R2 is thought to be the primary inducer of VEGF-mediated blood vessel growth, while VEGF R3 plays a significant role in VEGF-C and VEGF-D-mediated lymphangiogenesis.
Formulation
Lyophilized in PBS
Specificity
The antibody will detect native human VEGFR-2/KDR in ELISA and on the surface of different human cell types.
Immunogen
Recombinant human soluble KDR (D7)
Purification
Protein G chromatography
Reconstitution
Centrifuge vial prior to opening. Add sterile distilled water to the vial to fully solubilize the antibody to a concentration of 0.1 to 1.0 mg/ml.
Storage and Stability
The lyophilized product, though stable at room temperature for three weeks, is best stored desiccated at -20C to -80C. Reconstituted protein is stable for two weeks at +2C to +4C, or for longer storage at -20C to -80C. Store in working aliquots. Avoid repeated freeze-thaw cycles.
Application Notes
Western Blot: Use at 2-5 ug/mlFACS: Use at 2-5 ug/mlIF/IHC: Use at 6-30 ug/mlELISA: Use at 1-10 ug/ml The optimal concentration should be determined by the user for each specific application.
Menge: 100 ug
Lieferbar: In stock
Listenpreis: 543,94 €
Preis: 543,94 €
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