Antibodies

Rabbit Anti-Human Bcl-xL/BCL2L1 Affinity Purified pAb

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Hersteller Cell Sciences
Kategorie
Typ Antibody
Specific against Human
Isotype IgG
Applikationen WB
Menge 100 ug
Host Rabbit
ArtNr CS-CPB104
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Applications
For Western Blot, use a working dilution of 0.5-4 ug/ml. For Immunoprecipitation, use a working dilution of 20 ug/ml. Blocking Peptide (Cat. No. CPB104BP) available separately. The optimal concentration should be determined by the user for each specific application.
Description
Rabbit Anti-Multispecies BCL2L1 Affinity Purified polyclonal antibody. BCL2L1 is a 30 kDa anti-apoptotic protein belonging to the BCL2 family. BCL2L1 prevents apoptosis through two different mechanisms: by heterodimerization with an apoptotic protein to inhibit its apoptotic effect, and by its direct pore-forming effect on the outer-membrane of mitochondria to help maintain a normal membrane state under stress conditions. BCL2L1 can be cleaved by caspases upon apoptotic activation, which converts BCL2L1 from, an antiapoptotic protein to a proapoptotic cleavage product. The cleavage product of BCL2L1 forms cytochrome c-releasing pores in the mitochondrial membrane to facilitate the apoptosis signaling pathway.
Formulation
Liquid in PBS, pH 7.2 + 30% glycerol + 0.5% BSA + 0.01% thimerosal. Precaution: Thimerosal is a poisonous and hazardous substance which should be handled by trained staff only.
Specificity
Human, mouse, rat. Detects the 30 kDa BCL2L1 protein.
Immunogen
Synthetic peptide surrounding amino acid 56 of human BCL2L1
Purification
Biospecific affinity chromatography
Storage and Stability
Store at -20C or in working aliquots at -80C for long term storage. Avoid repeated freeze-thaw cycles.
Cross-Reactivity
Does not react with other BCL2 family members.

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Menge: 100 ug
Lieferbar: In stock
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