Rabbit Anti-Human CASP6 Active Affinity Purified pAb

Rabbit Anti-Human Active Caspase 6 Affinity Purified polyclonal antibody. The caspase family of cysteine proteases has been shown to play a key role in apoptosis. Similar to other caspases, caspase 6 is synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Together with caspase 3, caspase 6 is one of the major caspases in apoptotic cells, and functions downstream of apoptosis inhibitors BCL2 and BCL-xL. Caspase 6 has also been shown to be involved in the proteolysis of poly (ADP-ribose) polymerase (PARP) and nuclear lamin A.

Detects the large subunit (18 kDa) of the active Caspase 6. Does not recognize other caspases.

Biospecific affinity chromatography

Reacts with human, mouse, and rat.