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Rabbit Anti-Human CASP12 pAb

ArtNr CS-CPC141A
Hersteller Cell Sciences
Menge 100 ug
Kategorie
Typ Antibody Polyclonal
Applikationen WB
Specific against Human (Homo sapiens)
Host Rabbit
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Similar products CASP12P1, CASP-12
Lieferbar
Manufacturer - Category
Antibodies
Storage Conditions
Caspase-12 antibody (Small) can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Application Notes
E, WB, IHC
Cross-Reactivity
Human
Description
Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including a-secretase presenilin and a-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-a. Caspase-12 is ubiquitously expressed in mouse tissues.
Formulation
Antibody is supplied in PBS containing 0.02% sodium azide. Precaution: Sodium azide is a poisonous and hazardous substance which should be handled by trained staff only.
Immunogen
Human Caspase-12 (Small) Peptide
Purification
Affinity chromatography purified via peptide column

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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