Rabbit Anti-Human CASP12 pAb

Antibodies

E, WB, IHC

Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including a-secretase presenilin and a-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-a. Caspase-12 is ubiquitously expressed in mouse tissues.

Human Caspase-12 (Small) Peptide