Antibodies

Mouse Anti-Mouse VEGFR3/FLT4 mAb

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Hersteller Cell Sciences
Kategorie
Typ Antibody
Specific against Mouse
Isotype IgG1
Applikationen WB
Menge 200 ug
Host Mouse
ArtNr CS-CMV130
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Applications
Western Blot Immunohistochemistry The optimal concentration should be determined by the user for each specific application.
Description
Mouse Anti-mouse VEGFR3 Antagonistic monoclonal antibody. The mAb was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with mouse VEGFR-3 N-terminal recombinant protein. VEGFR-3, also known as FLT4, is a member of the Tyr protein kinase family. The extracellular portion of VEGFR-3 contains 7 immunoglobulin (Ig)-like domains and the cytoplasmic portion contains a protein kinase domain. FLT4 regulates angiogenesis and lymphangiogenesis, its ligands are VEGF-C and D and its binding is mediated by the 2nd and 3rd Ig-like domains of FLT4. During fetal development VEGFR-3 is expressed on endothelial cells, however, in the adult mice, the vascular endothelial cells lose VEGFR-3 expression, but the lymphatic endothelium expresses it constitutively. In addition, VEGFR-3 expression can be induced in tumors with active angiogenesis.
Formulation
Lyophilized from a 0.2 um sterile filtered solution in PBS
Specificity
Mouse VEGFR3
Immunogen
Mouse VEGFR3 N-terminal recombinant protein
Purification
Protein G affinity chromatography
Reconstitution
Centrifuge vial prior to opening. Reconstitute with sterile PBS.
Storage and Stability
Store lyophilized antibody at -80C. Reconstituted antibody is stable for six months in working aliquots at -80C. Avoid repeated freeze-thaw cycles.

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Menge: 200 ug
Lieferbar: In stock
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