Mouse Anti-Mouse VEGFR3/FLT4 mAb

Mouse Anti-mouse VEGFR3 Antagonistic monoclonal antibody. The mAb was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with mouse VEGFR-3 N-terminal recombinant protein. VEGFR-3, also known as FLT4, is a member of the Tyr protein kinase family. The extracellular portion of VEGFR-3 contains 7 immunoglobulin (Ig)-like domains and the cytoplasmic portion contains a protein kinase domain. FLT4 regulates angiogenesis and lymphangiogenesis, its ligands are VEGF-C and D and its binding is mediated by the 2nd and 3rd Ig-like domains of FLT4. During fetal development VEGFR-3 is expressed on endothelial cells, however, in the adult mice, the vascular endothelial cells lose VEGFR-3 expression, but the lymphatic endothelium expresses it constitutively. In addition, VEGFR-3 expression can be induced in tumors with active angiogenesis.

Mouse VEGFR3 N-terminal recombinant protein

Centrifuge vial prior to opening. Reconstitute with sterile PBS.