Antibodies

Rabbit Anti-Mouse Casp9 pAb

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Hersteller Cell Sciences
Kategorie
Typ Antibody
Specific against Mouse
Isotype IgG
Applikationen WB
Menge 100 ug
Host Rabbit
ArtNr CS-CPC126
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Applications
Western Blot
Description
Rabbit Anti-Mouse Caspase 9 polyclonal antibody. Caspase 9 is one of the most important caspases among the caspase family members. Upon induction of apoptosis, cytochrome c released from mitochondria associates with procaspase 9/APAF1. The complex processes procaspase 9 into a large subunit (35 kDa or 17 kDa) and small (10 kDa) by self-cleavage at D315. Activated caspase 9 further cleaves other caspase members including caspase 3, one of the proteases responsible for the proteolytic cleavage of many key proteins in apoptosis. In addition to self-cleavage, procaspase 9 can also be cleaved in vivo by caspase 3 at D330. The process served as a positive feedback to amplify the apoptotic signal in caspase activation pathway.
Formulation
Liquid in PBS, pH 7.2 + 30% glycerol + 0.5% BSA + 0.01% thimerosal. Precaution: Thimerosal is a poisonous and hazardous substance which should be handled by trained staff only.
Specificity
Detects 45 kDa Procaspase 9, 35/37 kDa cleaved large fragment, and the 25 kDa fully cleaved Caspase 9.
Immunogen
Synthetic peptide surrounding amino acid 345 of mouse Caspase 9
Purification
Protein A purified
Storage and Stability
Store at -20C or in working aliquots at -80C for long term storage. Avoid repeated freeze-thaw cycles.
Cross-Reactivity
Reacts with mouse and rat.

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Menge: 100 ug
Lieferbar: In stock
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