Rabbit Anti-Mouse MAPKAPK2 Affinity Purified pAb

Rabbit Anti-Mouse MAPKAPK2 Affinity Purified polyclonal antibody. MAPKAPK2, also known as p45 hsp27 kinase, is a 45-54 kDa serine-threonine protein kinase that contains a proline rich sequence and two putative SH3-binding sites. MAPKAPK2 is activated in response to stress, IL1, and TNF, possibly catalyzed by p38/Hog-dependent phosphorylation. Hsp27 is one of the major substrates of MAPKAPK2, it stimulates actin polymerization in order to facilitate recovery from destruction of the cytoskeleton during cellular stresses. Two isoforms differing in their C-terminals are produced due to alternative splicing of the same gene. This antibody recognizes both isoforms.

Synthetic peptide surrounding amino acid 365 of mouse MAPKAPK2

Store at -20C or in working aliquots at -80C. Avoid repeated freeze-thaw cycles.