Antibodies

Rabbit Anti-Multispecies BOK Affinity Purified pAb

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Hersteller Cell Sciences
Kategorie
Typ Antibody
Specific against Rat
Isotype IgG
Applikationen WB
Menge 100 ug
Host Rabbit
ArtNr CS-CPB118
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Applications
Western Blot
Description
Bok (Bcl-2-related ovarian killer) is a pro-apoptotic Bcl-2 family protein identified in the ovary based on its dimerization with the anti-apoptotic protein Mcl-1. In addition to the Bcl-2 homology (BH) domains 1 and 2 and the transmembrane sequence, Bok also has a BH3 domain believed to be important for dimerization with selective anti-apoptotic Bcl-2 proteins and cell killing. Bok interacts strongly with some (Mcl-1, BHRF1, and Bfl-1) but not other (Bcl-2, Bcl-xL, and Bcl-w) anti-apoptotic members. In addition, cell killing induced by Bok was suppressed following coexpression with Mcl-1 and BHRF1, but not with Bcl-2, further indicating that Bok heterodimerized only with selective anti-apoptotic Bcl-2 proteins. Bok was highly expressed in the ovary, testis and uterus.
Formulation
100 ug (0.2 mg/ml) peptide affinity purified rabbit anti-Bok polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol + 1% BSA + 0.02% thiomersal. Precaution: Thiomersal is a poisonous and hazardous substance which should be handled by trained staff only.
Specificity
The antibody detects the 18 kDa recombinant rat BOK expressed in, E. coli, .
Immunogen
Synthetic peptide surrounding amino acid 44 of rat BOK
Purification
Affinity purified
Storage and Stability
Store at -20C or in working aliquots at -80C for long term storage. Avoid repeated freeze-thaw cycles.
Concentration
0.2 mg/ml
Cross-Reactivity
Mouse and rat. Though it has not been tested, human shares 100% homology with the immunogen.
Application Notes
For Western Blot, use a working dilution of 0.5-4 ug/ml.The optimal concentration should be determined by the user for each specific application.

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Menge: 100 ug
Lieferbar: In stock
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