« Back
Home /
Rabbit Anti-Multispecies BOK Affinity Purified pAb

Rabbit Anti-Multispecies BOK Affinity Purified pAb

Manufacturer	Cell Sciences
Category	Oncology Antibodies By Cell Type Blastoma Carcinoma Hematology Leukemia Lymphoma Myeloma Cell Biology Cell Status Apoptosis Western Blot Autophagy Primary Antibodies By Organ Colorectal Cancer Testicular & Prostate Cancer Uterine, Ovarian & Cervical Cancer
Type	Antibody Polyclonal
Specific against	Rat
Isotype	IgG
Applications	WB
Amount	100 ug
Host	Rabbit
Item no.	CS-CPB118
Targets	CD262, BCL2
eClass 6.1	32160702
eClass 9.0	32160702
Available
Application Notes	For Western Blot, use a working dilution of 0.5-4 ug/ml.The optimal concentration should be determined by the user for each specific application.
Concentration	0.2 mg/ml
Cross-Reactivity	Mouse and rat. Though it has not been tested, human shares 100% homology with the immunogen.
Description	Bok (Bcl-2-related ovarian killer) is a pro-apoptotic Bcl-2 family protein identified in the ovary based on its dimerization with the anti-apoptotic protein Mcl-1. In addition to the Bcl-2 homology (BH) domains 1 and 2 and the transmembrane sequence, Bok also has a BH3 domain believed to be important for dimerization with selective anti-apoptotic Bcl-2 proteins and cell killing. Bok interacts strongly with some (Mcl-1, BHRF1, and Bfl-1) but not other (Bcl-2, Bcl-xL, and Bcl-w) anti-apoptotic members. In addition, cell killing induced by Bok was suppressed following coexpression with Mcl-1 and BHRF1, but not with Bcl-2, further indicating that Bok heterodimerized only with selective anti-apoptotic Bcl-2 proteins. Bok was highly expressed in the ovary, testis and uterus.
Formulation	100 ug (0.2 mg/ml) peptide affinity purified rabbit anti-Bok polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol + 1% BSA + 0.02% thiomersal. Precaution: Thiomersal is a poisonous and hazardous substance which should be handled by trained staff only.
Immunogen	Synthetic peptide surrounding amino acid 44 of rat BOK
Purification	Affinity purified
Storage and Stability	Store at -20C or in working aliquots at -80C for long term storage. Avoid repeated freeze-thaw cycles.
Specificity	The antibody detects the 18 kDa recombinant rat BOK expressed in, E. coli, .

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

CS-CPB118-datasheet.pdf

Request safety datasheet

Simple Order Order Subscription

Amount: 100 ug

available

Delivery expected until 5/23/2024