Rabbit Anti-Rat TYROBP/DAP12 pAb

4C for short term storage or -20C in small aliquots for long term storage. Avoid repeated freeze-thaw cycles.

DAP12 (KARAP) is a natural killer (NK) cell-expressed cell surface receptor and belongs to the immunoglobulin and C-type lectin superfamily. Unlike other members of this family which possess immunoreceptor tyrosine-based inhibitory motifs (ITIM), DAP12 contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain and is a disulfide-bonded homodimer. Crosslinking of DAP12-KIR complexes (membrane glycoproteins of the killer-cell inhibitory receptor family without an ITIM in their cytoplasmic domain) results in cellular activation.

Recombinant DAP12 peptide (amino acids 28-40)

Centrifuge vial prior to opening. Reconstitute to 1 mg/ml by adding 200 ul PBS.