Recombinant Human ASK1/MAP3K5 (aa 649-946) GST Active *di

Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against Human
Menge 5 ug
Host Insect
ArtNr CS-CRA216A
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Description
Apoptosis Signal-regulating Kinase 1 (ASK1), also known as MAPKKK5 (MAP3K5), activates MKK3, MKK4 (SEK1), and MKK6. Overexpression of ASK1 induces apoptotic cell death, and ASK1 is activated in cells treated with TNF-alpha. ASK1 interacts with members of the TRAF family and is activated by TRAF2 in the TNF-signaling pathway. After activation by TRAF2, ASK1 activates MKK4, which in turn activates JNK. Thus, ASK1 is a mediator of TRAF2-induced JNK activation.
Formulation
Liquid in 50 mM Tris-HCl, pH 7.5 + 150 mM NaCl + 0.25 mM DTT + 0.1 mM EGTA + 0.1 mM EDTA + 0.1 mM PMSF + 25% Glycerol
Storage and Stability
Stable for 1 year in working aliquots at -80C. Avoid repeated freeze-thaw cycles.
Concentration
0.1 mg/mL
GeneID
4217
Source
Sf9 insect cells
Molecular Weight
60 kDa
Purity
>90%
Specific Activity
96 nmol/min/mg
Menge: 5 ug
Lieferbar: In stock
Listenpreis: 489,34 €
Preis: 489,34 €
lieferbar

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