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Recombinant Human ASK1/MAP3K5 (aa 649-946) GST Active

Recombinant Human ASK1/MAP3K5 (aa 649-946) GST Active

Manufacturer	Cell Sciences
Category	Metabolism Diabetes Glucose Homeostasis Peptides & Proteins Recombinant Proteins Cardiovascular Research Ischemia & Reperfusion Injury
Type	Proteins
Specific against	Human
Amount	5 ug
Host	Insect
Item no.	CS-CRA216A
Conjugate/Tag	GST
eClass 6.1	34160400
eClass 9.0	42020190
Available
Concentration	0.1 mg/mL
Description	Apoptosis Signal-regulating Kinase 1 (ASK1), also known as MAPKKK5 (MAP3K5), activates MKK3, MKK4 (SEK1), and MKK6. Overexpression of ASK1 induces apoptotic cell death, and ASK1 is activated in cells treated with TNF-alpha. ASK1 interacts with members of the TRAF family and is activated by TRAF2 in the TNF-signaling pathway. After activation by TRAF2, ASK1 activates MKK4, which in turn activates JNK. Thus, ASK1 is a mediator of TRAF2-induced JNK activation.
Formulation	Liquid in 50 mM Tris-HCl, pH 7.5 + 150 mM NaCl + 0.25 mM DTT + 0.1 mM EGTA + 0.1 mM EDTA + 0.1 mM PMSF + 25% Glycerol
Molecular Weight	60 kDa
Storage and Stability	Stable for 1 year in working aliquots at -80C. Avoid repeated freeze-thaw cycles.
Specificity	96 nmol/min/mg

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.