Recombinant Human BDNF

Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against Human
Menge 1.0 mg
Host E.coli
ArtNr CS-CRB600C
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Description
Brain Derived Neurotrophic Factor, or BDNF, is a nerve growth factor that supports neuron growth and survival. BDNF shares identical domains with two other neurotrophic factors known as, β, -NGF and NT-3 (neurotrophin-3). BDNF binds with low affinity to a receptor known as LNGFR, which also binds NGF and NT-3, but mediates survival function by signaling through a high affinity receptor known as gp145/TrkB. Human, mouse, rat and pig BDNF are all cross-reactive. Recombinant human BDNF is a non-glycosylated homodimer, containing two 119 amino acid chains, with a total molecular weight of 27 kDa.
Formulation
Lyophilized from a sterile filtered solution without additives.
Reconstitution
Centrifuge vial prior to opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. Reconstitute the lyophilized product with sterile water at a concentration of 0.1 mg/ml. After complete solubilization of the protein, it can be further diluted into other aqueous solutions.
Storage and Stability
Store desiccated at -20C. After reconstitution, store in working aliquots at -20C. Avoid repeated freeze-thaw cycles.
GeneID
627
Source
E. coli
Molecular Weight
27.0 kDa
Purity
97.0% by HPLC, reducing and non-reducing SDS-PAGE, and UV spectroscopy at 280 nm
Endotoxin Level
<=1 EU/ug protein
Biological Activity
Determined by the dose dependent proliferation of C6 cells and typically between 0.5-1.5 ug/ml.
AA Sequence
MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR
Menge: 1.0 mg
Lieferbar: In stock
Listenpreis: 5.827,57 €
Preis: 5.827,57 €
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