Recombinant Human BDNF

Store desiccated at -20C. After reconstitution, store in working aliquots at -20C. Avoid repeated freeze-thaw cycles.

Brain Derived Neurotrophic Factor, or BDNF, is a nerve growth factor that supports neuron growth and survival. BDNF shares identical domains with two other neurotrophic factors known as, β, -NGF and NT-3 (neurotrophin-3). BDNF binds with low affinity to a receptor known as LNGFR, which also binds NGF and NT-3, but mediates survival function by signaling through a high affinity receptor known as gp145/TrkB. Human, mouse, rat and pig BDNF are all cross-reactive. Recombinant human BDNF is a non-glycosylated homodimer, containing two 119 amino acid chains, with a total molecular weight of 27 kDa.

Centrifuge vial prior to opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. Reconstitute the lyophilized product with sterile water at a concentration of 0.1 mg/ml. After complete solubilization of the protein, it can be further diluted into other aqueous solutions.

<=1 EU/ug protein