Recombinant Human M-CSF/CSF1 HQ

M-CSF (macrophage colony stimulating factor, colony stimulating factor 1, CSF-1) is a hemtopoietic growth factor produced by monocytes, granulocytes, endothelial cells, fibroblasts and activated B-cells and T-cells. M-CSF stimulates macrophage colony formation and regulates proliferation and differentiation of hematopoeitic stem cells into macrophages and regulates survival and differentiation of monocytes. It enhances antibody-dependent cell-mediated cytotoxity, enhances marophage killing of tumor cells and microorganisms, regulates the release of cytokines and inhibits bone resorption by osteoclasts. Human M-CSF shows biological ativity on mouse and rat cells and although mouse M-CSF is active in rat cells it is inactive in human cells

Lyophilized from PBS, pH 7.2, sterile filtered through a 0.2 um filter.

Centrifuge vial prior to opening. Reconstitute the lyophilized protein in sterile water to a concentration of no less than 100 ug/ml. The solution can be further diluted into aliquots in aqueous buffers. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). The optimal concentration should be determined by the user for each specific application.

> 5 x 10E5 U/mg