Recombinant Human M-CSF

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Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against Human
Menge 1.0 mg
Host Baculovirus
ArtNr CS-CRM151C
eClass 6.1 34160400
eClass 9.0 42020190
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Description
Macrophage Colony Stimulating Factor (M-CSF) is a four alpha helical bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation. M-CSF is also essential for the survival and proliferation of osteoclast progenitors. M-CSF also primes and enhances macrophage killing of tumor cells and microorganisms, regulates the release of cytokines and other inflammatory modulators from macrophages, and stimulates pinocytosis. As a result of glycosylation, the recombinant protein migrates with an apparent MW = 42.0 +/- 4.2 kDa in SDS-PAGE, a covalently linked homodimer, of two 21 kDa polypeptide monomers.
Formulation
Lyophilized from sterile filtered solution in 20 mM PB + 1% HSA + 3% Mannitol
Reconstitution
Centrifuge vial prior to opening to bring contents to bottom. Add sterile distilled water to a concentration of 0.1 mg/ml. Further dilutions should be made in appropriate buffered solutions.
Storage and Stability
Stable at 2-4C, but best kept desiccated at -20C. Upon reconstitution, stable for up to 1 week at 2-4C. For longer term, store in working aliquots at -20C to -80C. Avoid repeated freeze/thaw cycles.
GeneID
1435
Source
Baculovirus infected Silkworm
Molecular Weight
42.0 kDa
Purity
>95% by SDS-PAGE and HPLC
Specific Activity
>3.3 x 105 IU/mg.
Endotoxin Level
<1 EU/ug
Biological Activity
ED50 is <3.0 ng/mL, determined by the dose-dependant stimulation of the proliferation of mouse M-NSF-60 cells.
AA Sequence
EEVSEYCSHM IGSGHLQSLQ RLIDSQMETS CQITFEFVDQ EQLKDPVCYL KKAFLLVQDI MEDTMRFRDN TPNAIAIVQL QELSLRLKSC FTKDYEEHDKACVRTFYETP LQLLEKVKNV FNETKNLLDK DWNIFSKNCN NSFAECSSQ

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Menge: 1.0 mg
Lieferbar: In stock
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