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Recombinant Human NGB/Neuroglobin

Recombinant Human NGB/Neuroglobin

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Hersteller	Cell Sciences
Kategorie	Proteins
Typ	Proteins
Specific against	Human
Menge	10 ug
Host	E.coli
ArtNr	CS-CRN007B
eClass 6.1	34160400
eClass 9.0	42020190
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Description	Neuroglobin is a recently identified member of the globin superfamily expressed primarily in the vertebrate brain and retina. Neuroglobin promotes survival of neurons upon hypoxic injury by augmenting O2 supply, thereby potentially limiting brain damage. Moreover, neuroglobin may be a novel oxidative stress-responsive sensor for signal transduction in the brain. Neuroglobin expression is increased by neuronal hypoxia, in vitro, and focal cerebral ischemia, in vivo . Neuronal survival after hypoxia is reduced by inhibiting neuroglobin expression with an antisense oligodeoxynucleotide and enhanced by neuroglobin overexpression. Recombinant Human Neuroglobin contains 151 aa residues.
Formulation	Sterile filtered and lyophilized from a 0.5 mg/ml solution containing 0.05 M phosphate buffer + 0.1 M NaCl, pH 7.2.
Reconstitution	Centrifuge vial prior to opening. Add 0.2 ml of distilled water and let the lyophilized pellet dissolve completely.
Storage and Stability	Store lyophilized protein at -20C. The lyophilized protein remains stable until the expiration date when stored at -20C. Aliquot the product after reconstitution and store at -20 to -80C. Avoid repeated freeze-thaw cycles.
GeneID	58157
Source	E. coli
Molecular Weight	17 kDa
Purity	> 95% as determined by SDS-PAGE.
AA Sequence	MERPEPELIR QSWRAVSRSP LEHGTVLFAR LFALEPDLLP LFQYNCRQFS SPEDCLSSPE FLDHIRKVML VIDAAVTNVE DLSSLEEYLA SLGRKHRAVG VKLSSFSTVG ESLLYMLEKC LGPAFTPATR AAWSQLYGAV VQAMSRGWDG E.

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