Recombinant Human NGB/Neuroglobin

Store lyophilized protein at -20C. The lyophilized protein remains stable until the expiration date when stored at -20C. Aliquot the product after reconstitution and store at -20 to -80C. Avoid repeated freeze-thaw cycles.

Neuroglobin is a recently identified member of the globin superfamily expressed primarily in the vertebrate brain and retina. Neuroglobin promotes survival of neurons upon hypoxic injury by augmenting O2 supply, thereby potentially limiting brain damage. Moreover, neuroglobin may be a novel oxidative stress-responsive sensor for signal transduction in the brain. Neuroglobin expression is increased by neuronal hypoxia, in vitro, and focal cerebral ischemia, in vivo . Neuronal survival after hypoxia is reduced by inhibiting neuroglobin expression with an antisense oligodeoxynucleotide and enhanced by neuroglobin overexpression. Recombinant Human Neuroglobin contains 151 aa residues.

Centrifuge vial prior to opening. Add 0.2 ml of distilled water and let the lyophilized pellet dissolve completely.