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Recombinant Human TNF-beta

Recombinant Human TNF-beta

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Hersteller	Cell Sciences
Kategorie	Proteins
Typ	Proteins
Specific against	Human
Menge	1.0 mg
Host	E.coli
ArtNr	CS-CRT103C
eClass 6.1	34160400
eClass 9.0	42020190
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Description	Lymphotoxin alpha, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. LTA is highly inducible, secreted, and exists as homotrimeric molecule. LTA forms heterotrimers with lymphotoxin-beta which anchors lymphotoxin-alpha to the cell surface. LTA mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. LTA is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Recombinant Human TNF-beta is a single, non-glycosylated, polypeptide chain containing 172 amino acids and purified by proprietary techniques.
Formulation	Sterile filtered and then lyophilized with no additives.
Reconstitution	Centrifuge vial prior to opening. First add sterile water to the vial to fully solubilize the protein to a concentration not less than 100 ug/ml. After complete solubilization of the protein, it can be further diluted to other aqueous solutions.
Storage and Stability	Store lyophilized protein at -20C to -80C. Reconstituted protein is stable for 1 week at 2-4C. For long term storage, aliquot and store at -20C to -80C with a carrier protein such as 0.1% HSA or BSA as a stabilizer. This depends upon the particular application employed. Avoid repeated freeze-thaw cycles.
GeneID	4049
Source	E. coli
Molecular Weight	18.645 kDa
Purity	>95.0% as determined by RP-HPLC and SDS-PAGE analyses.
Specific Activity	2 x 107 IU/mg.
Endotoxin Level	Less than 0.1 ng/ug (1 EU/ug) of recombinant Human TNF-beta.
Biological Activity	The ED50 as determined by the cytolysis of mouse L929 cells in the presence of Actinomycin D is < 0.05 ng/ml.
AA Sequence	MLPGVGLTPS AAQTARQHPK MHLAHSTLKP AAHLIGDPSK QNSLLWRANT DRAFLQDGFS LSNNSLLVPT SGIYFVYSQV VFSGKAYSPK ATSSPLYLAH EVQLFSSQYP FHVPLLSSQK MVYPGLQEPW LHSMYHGAAF QLTQGDQLST HTDGIPHLVL SPSTVFFGAF AL

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