Recombinant Human Phosphoglycerate Mutase 1 His

PGAM1 Recombinant Human although stable at 4C for 30 days, should be stored desiccated below -20C for periods greater than 30 days. Please avoid freeze-thaw cycles.

PGAM1 is part of the phosphoglycerate mutase family. PGAM1 is an essential component of glucose and 2, 3-BPGA (2, 3-bisphosphoglycerate) metabolism and catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. PGAM1 is a dimeric enzyme containing, in different tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). PGAM1 mutations lead to muscle phosphoglycerate mutase deficiency, a.k.a. glycogen storage disease X. PGAM1 Human Recombinant produced in, E. coli, is a single, non-glycosylated, polypeptide chain containing 274 amino acids (1-254 a.a.) and having a MW = 30.9 kDa. The PGAM1 is fused to an 20 amino acid His Tag at N-Terminus and purified by proprietary chromatographic techniques.