Recombinant Mouse PLAT/tPA Two-Chain Active *di

Store in working aliquots at -80C. Stable for 3 years from delivery. Avoid repeated freeze-thaw cycles.

Recombinant Mouse PLAT/tPA Two-Chain Active Form is >95% two chain, >95% active. Active Two-chain Recombinant Mouse Tissue Plasminogen Activator (PLAT/tPA) is produced by activation of the single-chain form with immobilized Plasmin. PLAT is a secreted serine protease which converts the proenzyme Plasminogen to the fibrinolytic enzyme Plasmin. PLAT is synthesized as a single chain which is cleaved by Plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism.

2.0 mg/ml