Synthetic Sincalide

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Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against other
Menge 5 mg
ArtNr CS-CRS140B
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Description
Sincalide also called CCK-8 has a molecular formula of C49H62N10O16S3 H-Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2. Sincalide corresponds to the C-terminal octapeptide of cholecystokinin (CCK) which acts on receptors within the gallbladder wall causing it to contract. Cholecystokinin (CCK) is a hormone originally isolated from pig intestinal mucosa and described as a linear 33-amino acid peptide containing a sulfated tyrosine, which is essential for its biological activity. It has been found in mammals in both the digestive tract and the central nervous system. Among its multiple biological functions, this hormone stimulates pancreatic exocrine secretion, gallbladder contraction, and intestine motility and may also act as a neurotransmitter/neuromodulator in the central nervous system.
Formulation
The Sincalide was lyophilized from a concentrated (1 mg/ml) solution with no additives.
Reconstitution
It is recommended to reconstitute the lyophilized Sincalide in sterile 18MU-cm water not less than 100 ug/ml, which can then be further diluted to other aqueous solutions
Storage and Stability
Lyophilized Sincalide although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution CCK-8 should be stored at 4C between 2-7 days and for future use below -18C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Molecular Weight
1143.29 Dalton
Purity
Greater than 98.0% as determined by analysis by RP-HPLC and Mass Spectral Anaylsis (MALDI-TOF exhibits correct Mw).

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Menge: 5 mg
Lieferbar: In stock
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