Recombinant HIV-I pol Integrase His

HIV-1 Integrase although stable at 4C for 1 week, should be stored below -18C. Please prevent freeze thaw cycles.

Integrase is an enzyme produced by the HIV which enables its genetic material to be integrated into the DNA of the infected cell and is a key component in the pre-integration complex. HIV integrase contains 3 domains, an N-terminal HH-CC zinc finger domain which is partially responsible for multimerization, a central catalytic domain and a C-terminal domain. Both Central catalytic domain and C-terminal domains have been shown to bind both viral and cellular DNA. No crystal structure data exists with Integrase bound to its DNA substrates. HIV-1 integrase functions as a dimer or a tetramer. Additionally, several host cellular proteins interact with integrase and may facilitate the integration process. The, E. coli, derived 26 kDa recombinant protein is a non-glycosylated polypeptide chain, containing the HIV-1 immunodominant regions from the pol protein (intergrase) and fused with six histidines at the N-terminus

Immunoreactive with all sera of HIV-1 infected individuals.