LOM612

2173232-79-4

C13H10N2O2S

DMSO : 6 mg/mL (23.23 mM; Need ultrasonic); H2O : < 0.1 mg/mL (insoluble)

Others

LOM612 is a potent activator of FOXO nuclear translocation, with an EC₅₀ value of 1.5 uM in cells. IC50 & Target: EC50: 1.5 uM (FOXO)^[1] In Vitro: LOM612 potently activates nuclear translocation of FOXO with an EC₅₀ value of 1.5 uM, and this effect is independent of CRM-1. LOM612 effectively induces translocation of endogenous FOXO3a and FOXO1, and increases the expression of the FOXO target genes p27 and FasL. LOM612 shows no effect on the nuclear export of endogenous NFKB2 transcription factor in U2OS cells. LOM612 is cytotoxic to HepG2 cells, with an IC₅₀ value of 0.64 uM, and does not sensitize non-cancer THLE2 cells (IC₅₀, 2.76 uM)^[1].