LOM612

Item no.	CS-0020741-50mg
Manufacturer	ChemScene
Amount	50mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	2173232-79-4
Available
CAS	2173232-79-4
Purity	>98%
Formula	C13H10N2O2S
MWt	258.30
Solubility	DMSO : 6 mg/mL (23.23 mM; Need ultrasonic); H2O : < 0.1 mg/mL (insoluble)
Clinical Information	No Development Reported
Pathway	Others
Target	Others
Biological Activity	LOM612 is a potent activator of FOXO nuclear translocation, with an EC₅₀ value of 1.5 uM in cells. IC50 & Target: EC50: 1.5 uM (FOXO)^[1] In Vitro: LOM612 potently activates nuclear translocation of FOXO with an EC₅₀ value of 1.5 uM, and this effect is independent of CRM-1. LOM612 effectively induces translocation of endogenous FOXO3a and FOXO1, and increases the expression of the FOXO target genes p27 and FasL. LOM612 shows no effect on the nuclear export of endogenous NFKB2 transcription factor in U2OS cells. LOM612 is cytotoxic to HepG2 cells, with an IC₅₀ value of 0.64 uM, and does not sensitize non-cancer THLE2 cells (IC₅₀, 2.76 uM)^[1].

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

CS-0020741-50mg-datasheet.pdf

Request safety datasheet

Simple Order Order Subscription

Amount: 50mg

available

Delivery expected until 11/6/2025

Express Delivery: Save 23 days

Compare

Add to wishlist

Get an offer