L-368,899 hydrochloride

160312-62-9

C26H43ClN4O5S2

DMSO : 130 mg/mL (219.88 mM; Need ultrasonic)

GPCR/G Protein

L-368, 899 hydrochloride is a potent, selective, orally bioavailable, non-peptide oxytocin receptor antagonist, with IC₅₀s of 8.9 nM and 26 nM for rat uterus and human uterus oxytocin receptor, respectively, used as a tocolytic agent. IC50 & Target: IC50: 8.9 nM (rat uterus oxytocin receptor), 26 nM (human uterus oxytocin receptor)^[1] In Vitro: L-368, 899 hydrochloride is a potent, orally bioavailable, non-peptide oxytocin receptor antagonist, with IC₅₀s of 8.9 nM and 26 nM for rat uterus and human uterus oxytocin receptor, respectively. L-368, 899 is less active on vasopressin receptor in human liver and kidney, rat liver and kidney (IC₅₀, 510 nM, 960 nM, 890 nM, 2400 nM, respectively)^[1].