Tannic acid

1401-55-4

C76H52O46

DMSO : 15 mg/mL (8.82 mM; Need ultrasonic and warming)

Membrane Transporter/Ion Channel

Tannic acid is a novel hERG channel blocker with IC₅₀ of 3.4 uM. IC50 & Target: IC50: 3.4 uM (hERG channel)^[1] In Vivo: During the course of treatment, tannic acid significantly ameliorates these phenotypes in AD skin lesions. Tannic acid treatment aslo reduces these dermal changes compare with AD mice. Treatment with tannic acid increases PPARgamma expression in AD skin sections. The PPARgamma protein expression is suppressed in vehicle-treated AD mice, but when treats with tannic acid, its expression is increased dramatically. The IL-1beta, TNFalpha, TNFR1, and COX2 protein expressions are significantly up-regulated in vehicle-treated AD mice, but significantly suppressed by tannic acid treatment^[2].