Comparison

Tannic acid

Item no. CS-7817-1g
Manufacturer ChemScene
Amount 1g
Category
Type Molecules
Specific against other
ECLASS 10.1 32169090
ECLASS 11.0 32169090
UNSPSC 12000000
Similar products 1401-55-4
Available
CAS
1401-55-4
Purity
>98%
Formula
C76H52O46
MWt
1701.20
Solubility
DMSO : 15 mg/mL (8.82 mM; Need ultrasonic and warming)
Clinical Information
Launched
Pathway
Membrane Transporter/Ion Channel
Target
Potassium Channel
Biological Activity
Tannic acid is a novel hERG channel blocker with IC50 of 3.4 uM. IC50 & Target: IC50: 3.4 uM (hERG channel)[1] In Vivo: During the course of treatment, tannic acid significantly ameliorates these phenotypes in AD skin lesions. Tannic acid treatment aslo reduces these dermal changes compare with AD mice. Treatment with tannic acid increases PPARgamma expression in AD skin sections. The PPARgamma protein expression is suppressed in vehicle-treated AD mice, but when treats with tannic acid, its expression is increased dramatically. The IL-1beta, TNFalpha, TNFR1, and COX2 protein expressions are significantly up-regulated in vehicle-treated AD mice, but significantly suppressed by tannic acid treatment[2].

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 1g
Available: In stock
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