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Human Claudin-18.2 Full Length Protein (VLP)

Human Claudin-18.2 Full Length Protein (VLP)

ArtNr	CL2-H52P7-100ug
Hersteller	ACROBiosystems
Menge	100 ug
Quantity options	100 ug 20 ug 500 ug
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Liquid
Specific against	Human (Homo sapiens)
Host	HEK293
Konjugat/Tag	Unconjugated
Dry ice	Yes
NCBI	NP_001002026.1
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Claudin-18.2,CLDN18,Claudin-18
Versandbedingung	Trockeneis
Lieferbar
Manufacturer - Category	Protein
Shipping Temperature	Dry ice
Storage Conditions	-70°C
Molecular Weight	27.7 kDa \| 56.1 kDa
Manufacturer - Format	Liquid
Description	Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14, 15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells.
Background	Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14, 15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells.
Molecule	Claudin-18.2
Exp Region	Met 1 - Val 261
Characteristics	This protein .
Endotoxin	1.0 EU per μg
Buffer	PBS, pH7.4
Stability	● The product MUST be stored at -70°C or lower upon receipt ● -70°C for 12 months under sterile conditions.
Protectant	trehalose

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CL2-H52P7-100ug-datasheet.pdf

CL2-H52P7-100ug-safety-datasheet.pdf