Anti Fish T-Cell Surface Glycoprotein CD4 mAb (Clone 6D1)

Antibodies/Primary Antibodies/Adaptive Immunity; Antibodies/Adaptive Immunity/Primary Antibodies; Research Area/Cell Types/T Cells/Primary Antibodies; Research Area/Immunology & Inflammation/Adaptive Immunity/Primary Antibodies; Research Area/Intercellular Communication/Receptors/Primary Antibodies

CAC

The two major subsets of T lymphocytes, helper and cytotoxic T cells, are defined by expression of CD4 and CD8 glycoproteins, respectively. T cells expressing the CD4 surface antigen facilitate B-cell maturation and production of antibodies by B-cells and are thus termed " helper" T cells. CD4+ helper T cells recognize exogenously derived peptides in the context of MHC class II molecule expressed on antigen presenting cells. One (D1) of four Ig-like extracellular domains of CD4 primarily interacts with the α 2 and β 2 domains of the MHC class II heterodimer. This antibody, raised against antigens from Ginbuna carp, permits flow cytometric and immunofluorescence analysis of CD4 helper T cells from zebrafish, goldfish and the cyprinid fish carp.
Source: Dr. Teruyuki Nakanishi, Department of Veterinary Medicine, Faculty of Materials Science and Technology, University of Japan
References:
1) Toda H., et al. Conservation of characteristics and functions of CD4 positive lymphocytes in a teleost fish. Dev Comp Immunol. (2011) 35 (6), 650-660.
2) Shibasaki Y., et al. Kinetics of CD4 + and CD8α + T-cell subsets in Graft-Versus-Host Reaction (GVHR) in Gimbuna crucian carp Carassius auratus langsdorfii.