Anti Collagen Alpha-1(VII) Chain mAb (Clone BML39)

Antibodies/Primary Antibodies/Basement membrane; Antibodies/Basement membrane/Primary Antibodies; Research Area/Cell Biology/Cytoskeleton/Primary Antibodies; Research Area/Cell Biology/Extracellular Matrix/Primary Antibodies; Research Area/Cell Biology/Signal Transduction/Primary Antibodies; Research Area/Disease/Epidermolysis Bullosa/Primary Antibodies; Research Area/Disease/TBDN/Primary Antibodies; Research Area/Disease/Nail disorder/Primary Antibodies; Research Area/Cell Biology/Cell Adhesion & Migration/Primary Antibodies; Research Area/Cell Biology/Cell Differentiation/Primary Antibodies; Research Area/Cell Types/Endodermal Cells/Primary Antibodies; Research Area/Cell Types/Epithelial Cells/Primary Antibodies; Research Area/Organelles & Subcellular Structures/Basement membrane/Primary Antibodies

This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in this gene are associated with all forms of dystrophic epidermolysis bullosa. The inherited disease, dystrophic epidermolysis bullosa, is caused by recessive or dominant mutations in COL7A1. In the absence of mutations, however, an autoimmune response against type VII collagen can result in an acquired form of this disease called epidermolysis bullosa acquisita. Type VII collagen is also found in the retina; its function in this organ is unknown. Collagen, type VII, alpha 1 has been shown to interact with Laminin 5 and Fibronectin.
Source: Nagoya University Graduate School of Science Department of Life Science Cell Biology Group Lecturer Mr. Yoshiko Hirako
References:
1) Uematsu J., et al. Eur J Cell Biol., 84: 407-415 (2005).
2) Hirako Y., et al. J. Biol. Chem., 273:9711-9717 (1998).

Monoclonal