Anti Transferrin Receptor (TFRC/CD71) mAb (Clone YUK9)

Antibodies/Iron Transport & Homeostasis/Primary Antibodies; Antibodies/Primary Antibodies/Iron Transport & Homeostasis; Research Area/Cell Biology/Cell Differentiation/Primary Antibodies; Research Area/Cell Biology/Cell Proliferation/Primary Antibodies; Research Area/Cell Biology/Endocytosis/Primary Antibodies; Research Area/Cell Biology/Hypoxic Metabolic & ER Stress/Primary Antibodies; Research Area/Cell Biology/Post Translational Modification & Processing/Primary Antibodies; Research Area/Cell Biology/Signal Transduction/Primary Antibodies; Research Area/Cell Types/B Cells/Primary Antibodies; Research Area/Cell Types/Osteoclasts/Primary Antibodies; Research Area/Cell Types/T Cells/Primary Antibodies; Research Area/Disease/Immunodeficiency/Primary Antibodies; Research Area/Immunology & Inflammation/Adaptive Immunity/Primary Antibodies; Research Area/Intercellular Communication/Receptors/Primary Antibodies; Research Area/Organelles & Subcellular Structures/Blood-Brain Barrier/Primary Antibodies; Research Area/Systemic Physiology/Acute Phase Response/Primary Antibodies; Research Area/Systemic Physiology/Aging/Primary Antibodies; Research Area/Systemic Physiology/Iron Transport & Homeostasis/Primary Antibodies

CD71 (also known as TFRC: transferrin receptor) is a widely expressed 180 kDa type II membrane glycoprotein involved in the cellular uptake of iron and in the regulation of cell growth. Iron uptake occurs via the internalization of iron-loaded transferrin mediated by the interaction with the CD71. CD71 expression is increased on rapidly proliferating cells, while expression is decreased or absent on non-dividing cells. Some studies have suggested that biologically aggressive tumorsrequire large amounts of iron for active metabolism and rapid cell growth, and overexpression of CD71 has reported in different types of cancers such as glioma, pancreatic, and colon cancers. In addition, CD71 is required for adult erythropoiesis and involved in T- and B- cell development. CD71 seems to play an important role in T cell activation, and T cells lacking CD71 are completely arrested at a very early stage of maturation. This antibody is specific to human CD71 and will be useful forFCM, immunoprecipitation.
Warnings]1. Not for diagnostic use. The safety and efficacy of product in diagnostic or other clinical uses has not been established. 2. Harmful by inhalation, in contact with skin and if swallowed. Do not breathe dust. Avoid contact with skin and eyes. 3. If contact with skin and eyes, wash all affected areas with large volume of water. If inhaled remove to fresh air. In severe case obtain medical attention. 4. Wash hand thoroughly after handling the product. 5.Do not use this product if container is broken or some contaminants are detected. 6. When preserving the product, Close the container, ensure it does not fall aside or down. 7. Dispose of the container and expired reagents in accordance with federal, state and local government regulations. 8. Do not use the container and accessories of the product for other purpose.

Monoclonal