Anti Tau, phospho Ser416 pAb

ArtNr	KAL-KR076
Hersteller	Cosmobio
Menge	25 ug
Kategorie	Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Antibodies Immunohistochemistry Primary Antibodies
Typ	Antibody Polyclonal
Format	Affinity Purified
Applikationen	IHC
Specific against	Human (Homo sapiens), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	Tau, phospho Ser416
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Manufacturer - Category	Antibodies/Neurodegeneration/Primary Antibodies; Antibodies/Primary Antibodies/Neurodegeneration; Research Area/Cell Biology/Autophagy/Primary Antibodies; Research Area/Cell Biology/Cytoskeleton/Primary Antibodies; Research Area/Cell Biology/DNA Damage & Repair/Primary Antibodies; Research Area/Cell Biology/Gene Expression & Transcription/Primary Antibodies; Research Area/Cell Biology/Oxidative Stress/Primary Antibodies; Research Area/Cell Biology/Signal Transduction/Primary Antibodies; Research Area/Cell Types/Astrocytes/Primary Antibodies; Research Area/Cell Types/Glial Cells/Primary Antibodies; Research Area/Cell Types/Neurons/Primary Antibodies; Research Area/Development/Brain & CNS/Primary Antibodies; Research Area/Disease/Frontotemporal dementia/Primary Antibodies; Research Area/Disease/Parkinson Disease/Primary Antibodies; Research Area/Disease/Pick disease of the brain/Primary Antibodies; Research Area/Disease/Progressive supranuclear palsy/Primary Antibodies; Research Area/Neurobiology/Axons/Primary Antibodies; Research Area/Neurobiology/Memory & Learning/Primary Antibodies; Research Area/Neurobiology/Neurodegeneration/Primary Antibodies; Research Area/Neurobiology/Synapses/Primary Antibodies; Research Area/Organelles & Subcellular Structures/Chromosomes/Primary Antibodies; Research Area/Organelles & Subcellular Structures/Microtubules/Primary Antibodies; Research Area/Organelles & Subcellular Structures/Mitochondria/Primary Antibodies; Research Area/Organelles & Subcellular Structures/Stress Granules/Primary Antibodies
Maker	KAL
Short Description	Rabbit Polyclonal: 2X epitope affinity purified. First vs cognate phospho-peptide then vs cognate non-phosphorylated peptide.
Description	Neurofibrillary tangles that are one of main pathological characteristics in the Alzheimer's disease (AD) brain are paired helical filaments (PHF) accumulated in the cell body of the neuron. The component of this PHF is known to be an excessively phosphorylated tau. Tau is one of proteins that stabilize microtubules and is necessary to form microtubules. However when it is excessively phosphorylated, it is thought that it disturbs microtubule formation, which causes neuronal cell death. There is a Ca2+/Calmodulin-dependent protein kinase II (CaM kinase II) as an enzyme that phosphorylates tau. It was especially found that its Ser 416 is strongly phosphorylated. Usually CaM kinase II abundantly exists in the synapses of the neurons, whereas it was reported that a large amount of Cam kinases II is accumulated in the cell bodies in the AD brain. This antibody was produced using a human tau peptide that is phosphorylated at Ser 416 as an antigen. It is expected to be useful to research about participation of tau and CaM kinase II in the development of AD.
Purification	Purified - Affinity
Clonality	Polyclonal

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Menge: 25 ug

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