Anti Laminin/Nidogen complex mAb (Clone 331G3)

Research Area/Development/Angiogenesis/Primary Antibodies; Antibodies/Primary Antibodies/Cell Adhesion & Migration; Antibodies/Cell Adhesion & Migration/Primary Antibodies; Research Area/Cell Biology/Cell Adhesion & Migration/Primary Antibodies; Research Area/Cell Biology/Extracellular Matrix/Primary Antibodies; Research Area/Disease/Poretti-Boltshauser syndrome/Primary Antibodies; Research Area/Development/Embryonic & Fetal Development/Primary Antibodies; Research Area/Development/Organogenesis/Primary Antibodies; Research Area/Neurobiology/Axons/Primary Antibodies; Research Area/Development/Vasculogenesis/Primary Antibodies; Research Area/Development/Salivary Glands/Primary Antibodies; Research Area/Development/Eye/Primary Antibodies; Research Area/Cell Biology/Signal Transduction/Primary Antibodies; Research Area/Development/Lung/Primary Antibodies; Research Area/Cell Types/Epithelial Cells/Primary Antibodies; Research Area/Cell Biology/Post Translational Modification & Processing/Primary Antibodies; Research Area/Organelles & Subcellular Structures/Basement membrane/Primary Antibodies; Research Area/Development/Kidney/Primary Antibodies

Nidogen-1 (originally also named entactin) and its homologue nidogen-2 are ubiquitous and highly conserved components of basement membranes (BMs), though nidogen-2 shows more restricted expression patterns throughout development and some tissue specificity in the adult [1-5]. In BMs nidogens play a fundamental role in linking the collagen type IV-laminins networks and in bridging these networks with oligomers of perlecan, matrilins and fibulins. Nidogen-1 is encoded by the NID1 gene and is translated as a 158 kDa globular protein containing three distinct globules with diverse ligand binding specificity. Gene deletion of either nidogen does not disrupt developmental BM assembly, whereas ablation of both NID1 and NID2 murine genes leads to BM abnormalities and prenatal death [6-8]. Alterations in nidogen-1 expression have been associated with neoplastic transformation (e.g. hepatocarcinoma, melanoma, bladder carcinoma, renal carcinoma, grastrointestinal cancer), skin, renal, retinal, muscle and connective tissue degenerative diseases.
References:
1) Carlin B, et all., J Biol Chem. 1981 May 25; 256(10):5209-14. PMID: 6262321
2) Timpl R, et all., Eur J Biochem. 1983 Dec 15; 137(3):455-65. PMID: 6420150
3) Kohfeldt E, et all., J Mol Biol. 1998 Sep 11; 282(1):99-109. PMID: 9733643
4) Ho MS, et all., Microsc Res Tech. 2008 May; 71(5):387-95. PMID: 18219668
5) Breitkreutz D, et all., Biomed Res Int. 2013; 2013:179784. PMID: 23586018
6) Murshed M, et all., Mol Cell Biol. 2000 Sep; 20(18):7007-12. PMID: 10958695
7) Miosge N, et all., Matrix Biol. 2002 Nov; 21(7):611-21. PMID: 12475645
8) Bader BL, et all., Mol Cell Biol. 2005 Aug; 25(15):6846-56. PMID: 16024816

Monoclonal