Recombinant Human Protein Kinase C (PKC) Alpha

Short term (up to 1year) store at –20°C. Long term, store at –70°C.

RecombinantHuman Protein Kinase C (PKC) Alpha. Not enzymatically active.

Purified, Liquid

20ug/ml

PRKCAprotein kinase C, alpha [ Homo sapiens ]

NP_002728

ATF-2 transcriptionfactor network, African trypanosomiasis, Aldosterone-regulated sodiumreabsorption, CaM pathway, Calmodulin induced events, Downstream signaling innaive CD8+ T cells, ErbB signaling pathway, Long-term depression, Naturalkiller cell mediated cytotoxicity, Trafficking of AMPA receptors, mTORsignaling pathway

Proteinkinase C alpha (PKCalpha), also known as PRKCA, refers to both a human gene andthe protein that is encoded by it. Protein kinase C (PKC) is a family ofserine- and threonine-specific protein kinases that can be activated bycalcium and the second messenger diacylglycerol. PKC family membersphosphorylate a wide variety of protein targets and are known to be involvedin diverse cellular signaling pathways. PKC family members also serve asmajor receptors for phorbol esters, a class of tumor promoters. Each memberof the PKC family has a specific expression profile and is believed to play adistinct role in cells. The protein encoded by this gene is one of the PKCfamily members. This kinase has been reported to play roles in many differentcellular processes, such as cell adhesion, cell transformation, cell cyclecheckpoint, and cell volume control. Knockout studies in mice suggest thatthis kinase may be a fundamental regulator of cardiac contractility and Ca2+handling in myocytes.