Recombinant Human Chemokine (C-X-C Motif) Ligand 12 (a. a. 68)

The lyophilized product is stable for a few weeks at roomtemperature but is best stored at –20°C. After reconstitution, aliquot andstore at –20°C.

Recombinant Chemokine (C-X-C motif) Ligand 12 (CXCL12) is arecently discovered protein belonging to the alpha chemokine (CXC) family ofcytokines. Recombinant Human CXCL12 is an 8kDa protein containing 68 aminoacid residues and which was expressed in E. coli.

Purified, Lyophilized We recommend a quick spin followed byreconstitution in water to a concentration of 0.1-1.0mg/ml. This solution canthen be diluted into other aqueous buffers and stored at 2-8C for one weekor –20C for future use.

Not applicable

CXCL12chemokine (C-X-C motif) ligand 12 [ Homo sapiens ]

NP_000600

Axonguidance, CXCR4-mediated signaling events, Chemokine signaling pathway, ClassA/1 (Rhodopsin-like receptors), G alpha (i) signalling events, HIF-1-alphatranscription factor network

SDF-1 (stromal cell-derived factor-1) is small cytokinebelonging to the chemokine family that is officially designated Chemokine(C-X-C motif) ligand 12 (CXCL12) Stromal cell-derived factors 1-alpha and1-beta are small cytokines that belong to the intercrine family, members ofwhich activate leukocytes and are often induced by proinflammatory stimulisuch as lipopolysaccharide, TNF, or IL1. The intercrines are characterized bythe presence of 4 conserved cysteines that form 2 disulfide bonds. They canbe classified into 2 subfamilies. In the CC subfamily, which includes betachemokine, the cysteine residues are adjacent to each other. In the CXCsubfamily, which includes alpha chemokine, they are separated by anintervening amino acid. The SDF1 proteins belong to the latter group