Recombinant Mouse Colony Stimulating Factor 3 (Granulocyte) (a. a. 179)

The ED50as determined by the dose-dependent stimulation of the proliferation ofmurine M-NFS-60 cells is< 0.05ng/ml, corresponding to a specificactivity of> 2x107 units/mg. Murine G-CSF is fullybiologically active when compared to standards. Each laboratory shoulddetermine an optimum working titer for use in its particular application.

Colony Stimulating Factor 3 (Granulocyte)

Csf3 (a.a. 179)

Lyophilized from10mM Sodium Citrate, pH 4.0.

None

NM_009971

Cytokine-cytokinereceptor interaction, Malaria, Jak-STAT signaling pathway, Hematopoietic celllineage, Cytokines and Inflammatory Response (BioCarta)

Granulocytecolony-stimulating factor (G-CSF or GCSF) is a colony-stimulating factorhormone. G-CSF is also known as colony-stimulating factor 3 (CSF 3). It is aglycoprotein, growth factor and cytokine produced by a number of differenttissues to stimulate the bone marrow to produce granulocytes and stem cells.G-CSF then stimulates the bone marrow to release them into the blood. G-CSFalso stimulates the survival, proliferation, differentiation, and function ofneutrophil precursors and mature neutrophils. G-CSF regulates them usingJanus kinase (JAK)/signal transducer and activator of transcription (STAT)and Ras /mitogen-activated protein kinase (MAPK) and phosphatidylinositol3-kinase (PI3K)/protein kinase B (Akt) signal transduction pathway.