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Recombinant Hepatitis B Virus (HBV) Core Antigen (HBcAg)(amino acids 1–183)

ArtNr DAG573
Hersteller Creative Diagnostics
Menge 0.5 mg
Kategorie
Typ Proteins Recombinant
Format Liquid
Specific against other
Purity 95%, pure (SDS-PAGE)
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Lieferbar
Manufacturer - Applications
Specific methodologies have not been tested using this, product.
Storage Conditions
Short-term store at 2–8oC. Long term, aliquot and, store at -80 C. Avoid multiple freeze/thaw cycles.
Full name
Hepatitis B Virus Core Antigen
Product Overview
HBV core antigen, (HBcAg) recombinant. Amino acids 1–183 of HBV core antigen, 18kDa. It reacts, to human HBV positive serum, and under non-reducing conditions, forms a, native core particle. It was cloned from HBV 320 genome, and expressed in, E.coli.
Background - Introduction
Hepatitis, B virus, abbreviated HBV, is a species of the genus Orthohepadnavirus, which is, likewise a part of the Hepadnaviridae family of viruses. The genome of HBV is, made of circular DNA, but it is unusual because the DNA is not fully, double-stranded. One end of the full length strand is linked to the viral DNA, polymerase. The genome is 3020-3320 nucleotides long (for the full length, strand) and 1700-2800 nucleotides long (for the short length strand). The, virus is divided into four major serotypes (adr, adw, ayr, ayw) based on, antigenic epitopes present on its envelope proteins, and into eight genotypes, (A-H) according to overall nucleotide sequence variation of the genome. The, genotypes have a distinct geographical distribution and are used in tracing, the evolution and transmission of the virus. Differences between genotypes, affect the disease severity, course and likelihood of complications, and response, to treatment and possibly vaccination.
Background - Keywords
HBV, HBVcore, Core antigen, Capsid protein, Core antigen, HBc, HBcA, Hepatitis B, Virus core antigen, p21.5, Hepadnaviridae, Orthohepadnavirus
Abbr
HBV Core (a.a. 1–183)
Manufacturer - Format
Purified, Liquid
Buffer
7.5mM, Phosphate buffer, 75mM Sodium chloride, pH 7.2 containing 50% glycerol
Concentration
1mg/ml (OD280nm)
Preservative
None
Antigen Description
Hepatitis B Virus, Core Antigen (HBcAg) is part of the infectious virion containing an inner, core particle enclosing the viral genome. The icosahedral core, particle contains 180 or 240 copies of the core protein. HBcAg is one of the, three major clinical antigens of hepatitis B virus but disappears early in, the course of infection. The hepatitis B virus core antigen (HBcAg) is a, highly immunogenic subviral particle and functions as both a T-cell-dependent, and a T-cell-independent antigen. Therefore, HBcAg may be a promising, candidate target for therapeutic vaccine control of chronic HBV infection.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 0.5 mg
Lieferbar: In stock
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