DNMT3A Antibody, Biotin conjugated

Polyclonal Antibody

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Human

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity

>95%, Protein G purified

Epigenetics and Nuclear Signaling

Recombinant Human DNA (cytosine-5)-methyltransferase 3A protein (680-902AA)