PVR Antibody

Polyclonal Antibody

PVR

CD155 antibody, CD155 antigen antibody, FLJ25946 antibody, HVED antibody, mE4 antibody, NECL 5 antibody, Necl-5 antibody, Necl5 antibody, Nectin like 5 antibody, Nectin like protein 5 antibody, Nectin-like protein 5 antibody, Ortholog of mouse Tage4 antibody, Poliovirus receptor antibody, PVR antibody, PVR_HUMAN antibody, PVS antibody, Taa1 antibody, Tage 4 antibody, TAGE4 antibody

Recombinant Human Poliovirus receptor protein (220-345AA)

Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.2 Publications

Antigen Affinity Purified

Microbiology

Recombinant Human Poliovirus receptor protein (220-345AA)