TRAF2 Antibody

TRAF2

E3 ubiquitin-protein ligase TRAF2 antibody; MGC:45012 antibody; OTTHUMP00000022625 antibody; OTTHUMP00000064745 antibody; TNF receptor associated factor 2 antibody; TNF receptor-associated factor 2 antibody; TNF receptor-associated protein antibody; TRAF 2 antibody; TRAF2 antibody; TRAF2_HUMAN antibody; TRAP 3 antibody; TRAP antibody; TRAP3 antibody; Tumor necrosis factor type 2 receptor associated protein 3 antibody; Tumor necrosis factor type 2 receptor-associated protein 3 antibody

Recombinant Human TNF receptor-associated factor 2 protein (147-281AA)

Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation, this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.

>95%, Protein G purified

Cell Biology

Recombinant Human TNF receptor-associated factor 2 protein (147-281AA)