TRAF6 Antibody

TRAF6

E3 ubiquitin-protein ligase TRAF6 antibody; Interleukin 1 signal transducer antibody; Interleukin-1 signal transducer antibody; MGC 3310 antibody; MGC:3310 antibody; MGC3310 antibody; OTTHUMP00000232772 antibody; OTTHUMP00000232773 antibody; RING finger protein 85 antibody; RNF 85 antibody; RNF85 antibody; TNF receptor associated factor 6 antibody; TNF receptor-associated factor 6 antibody; TNF receptor-associated factor 6; E3 ubiquitin protein ligase antibody; TRAF 6 antibody; Traf6 antibody; TRAF6_HUMAN antibody

Recombinant Human TNF receptor-associated factor 6 protein (1-522AA)

E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.

>95%, Protein G purified

Cell Biology

Recombinant Human TNF receptor-associated factor 6 protein (1-522AA)