ISG15 Antibody

ISG15

G1P2 antibody; hUCRP antibody; IFI 15 antibody; IFI15 antibody; Interferon alpha inducible protein antibody; Interferon induced protein 15 antibody; Interferon induced protein IFI-15K antibody; Interferon stimulated protein 15 kDa antibody; Interferon; alpha-inducible protein (clone IFI-15K) antibody; Interferon-induced 15 kDa protein antibody; Interferon-induced 17 kDa protein antibody; Interferon-induced 17-kDa/15-kDa protein antibody; IP17 antibody; ISG 15 antibody; ISG15 antibody; ISG15 ubiquitin like modifier antibody; ISG15_HUMAN antibody; Ubiquitin cross-reactive protein antibody; Ubiquitin-like protein ISG15 antibody; UCRP antibody

Recombinant Human Ubiquitin-like protein ISG15 protein (2-157AA)

Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. Seems to display antiviral activity during viral infections. Ref.12 Ref.13 Ref.14 Ref.15 Ref.20 Ref.21In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy

>95%, Protein G purified

Cell Biology

Recombinant Human Ubiquitin-like protein ISG15 protein (2-157AA)